ABSTRACT
Diabetes mellitus increases the risk of heart failure even in the absence of other co-morbidities. The present study is done to assess the diastolic dysfunction in diabetic patients and in correlating the grade of dysfunction with various parameters like age, gender, sex, glycaemic control, and microangiopathies associated with diabetes. We wanted to determine as to whether there is an association between diastolic dysfunction and type 2 DM and quantify the relation of LV diastolic dysfunction with age, duration of DM, HbA1c and obesity indices. We also wanted to assess the correlation between diastolic dysfunction and other microvascular complications of type 2 diabetes. METHODSThis is a cross sectional study. The sample size was 75. Assessment of the mitral peak velocity of early filling (E) and early diastolic mitral annular velocity (e’), and (E / e’) ratio is used to measure diastolic dysfunction. study was conducted on patients admitted in Goa Medical College. RESULTSAmong 75 subjects studied, 56 subjects (74.6 %) had diastolic dysfunction. There is a correlation of duration of diabetes with grade of diastolic dysfunction with a p value of 0.001. There is a correlation of dipstick proteinuria with grades of diastolic dysfunction with a p value of 0.002. Mean HbA1c in patients with grade 0 dysfunction was 7.93 with standard deviation of 0.86, grade 1 dysfunction was 7.28 with a standard deviation of 0.71, grade 2 dysfunction was 9.72 with standard deviation of 1.86, grade 3 dysfunction was 11.94 with standard deviation of 2.05 with a p value of < 0.001. CONCLUSIONSDiabetes is an independent risk factor for cardiovascular disease in the form of diastolic dysfunction in the initial stages. The grade of dysfunction was proportional to duration of diabetes, blood sugar levels, and mean HbA1c. Diastolic dysfunction also correlates with other microvascular complications of diabetes.
ABSTRACT
Background: Head and neck cancer (HNC) represents 3% of all the malignant tumours. It is the sixth most commonhuman malignancy. Patients with head and neck cancer receiving radiotherapy are exposed to ionizing radiationwhich may damage normal tissue located in the field of radiation. The present study aims to determine thechanges in antioxidants status of pre and post RT saliva samples of HNC patientsMaterials and Methods: The pre and post radiotherapy saliva samples were collected from every patient withhead and neck cancer. The changes in the antioxidant levels of saliva in pre and post radiotherapy salivasamples of head and neck cancer patients was determined.Observation: The three biochemical parameters levels Malondealdehyde, Glutathione peroxidase,Myeloperoxidase decreased following radiotherapy. But the decrease was not statistically significant forGlutathione peroxidase and Myeloperoxidase and highly significant for Malondealdehyde.Conclusion: The Total Antioxidant Capacity increased following radiotherapy and it was observed that afterradiotherapy their increased levels were statistically not significant.
ABSTRACT
Patients with head and neck cancer receiving radiotherapy in addition to antitumour effects also are exposed toionizing radiation which may also damage normal tissue located in the field of radiation. The study was done onbuccal scrapings in patients with head and neck cancer patients receiving radiotherapy at the hospital. Thepresent study aims at determining the changes in MN in the buccal smears in pre and post RT in patients withhead and neck cancer patients. The mean number of MN was significantly high in buccal scrapings of patientspost RT suggesting DNA damage following exposure to radiations during RT.